Association between statin therapy and incident diabetes mellitus in patients with nephrotic syndrome: a retrospective cohort study.

ABSTRACT: The use of statins and other lipid-lowering therapies for nephrotic syndrome (NS) patients with dyslipidemia remains controversial. This study aimed to evaluate the impact of long-term statin therapy on the risk of developing diabetes mellitus (DM) in patients with NS. A retrospective cohort study was conducted from January 2018 to December 2024. The association between statin use and the incidence of diabetes was evaluated using Cox proportional hazards regression. Restricted cubic splines were utilized to investigate potential nonlinear relationships between cumulative statin dose and diabetes risk. Subgroup analyses were performed according to age, sex, corticosteroid use, and other relevant clinical factors to assess possible effect modification. A total of 837 eligible NS patients wer

SUBMITTER: Qian Y 

PROVIDER: S-EPMC12379507 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature