A Real-World Retrospective Observational Study of Patients with Advanced/Recurrent Endometrial Cancer Across England.

ABSTRACT:

Introduction

Robust real-world data (RWD) on endometrial cancer (EC) are lacking. In the United Kingdom (UK), molecular classification of EC based on tumour mismatch repair (MMR) status, either MMR-deficient (dMMR) or MMR-proficient (MMRp), has been recommended at diagnosis since 2020. This study characterised patients with advanced/recurrent EC, documented treatment pathways and evaluated clinical outcomes stratified by MMR status using RWD from National Health Service (NHS) trusts in England.

Methods

This retrospective, observational study captured electronic health records (EHRs) from seven NHS trusts from 2000 to 2023. Clinical outcomes included overall survival (OS) and time to next treatment (TTNT).

Results

Data were retrieved from 731 patients with EC (79% adva

SUBMITTER: Wallis J 

PROVIDER: S-EPMC12379663 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature