Dual-energy X-ray absorptiometry derived adiposity and colorectal cancer incidence and mortality in postmenopausal women.

ABSTRACT:

Background

Determine if dual-energy X-ray absorptiometry (DXA) derived adiposity was associated with colorectal cancer (CRC) incidence and mortality in postmenopausal women from the Women's Health Initiative (WHI) DXA Cohort.

Methods

Whole-body DXA scans estimated adiposity. Women with cancer history (except non-melanoma skin cancer) or missing baseline DXA were excluded. For 27 years of follow-up, outcomes and death were adjudicated. Descriptive statistics by CRC status were calculated. Fine and Gray's competing risks regression was used to estimate sub-hazard ratios (SHR) and 95% confidence intervals (CI). Observation time was from enrollment to first CRC event or competing risk (other cancer, other cause of death); women without cancer at last follow-up were censored. Cov

SUBMITTER: Ziller SG 

PROVIDER: S-EPMC12379803 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature