Management of Calvarial Osteoradionecrosis After Treatment of Cutaneous Malignancy: A Systematic Review.

ABSTRACT:

Objective

Osteoradionecrosis (ORN) is a recognized complication of radiotherapy. However, calvarial ORN (ORNC) following treatment for cutaneous malignancies is poorly understood. Shedding light on the limited evidence to date, this study aims to summarize existing evidence and highlight the research gaps.

Data sources

PubMed and Embase.

Review methods

A systematic search of PubMed and Embase was conducted up to May 2024, using relevant keywords to identify papers on ORNC. Data on the definition, incidence, risk factors, radiotherapy parameters, diagnostic methods, and management strategies were collected.

Results

Twenty articles reporting on 42 ORNC patients were identified, revealing relatively poor data quality. There remains no consensus on a definition of

SUBMITTER: Pang S 

PROVIDER: S-EPMC12379840 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature