Altered Glycosylation of PSA in Prostate Cancer Tissue.

ABSTRACT:

Background

The glycosylation of proteins is commonly altered in cancer. This offers novel opportunities for cancer biomarker development. As prostate-specific antigen (PSA) is a glycoprotein, identification of cancer-specific PSA-glycoforms is feasible. Such PSA-glycoforms may provide valuable diagnostic and prognostic information.

Methods

PSA-glycoforms were studied in tissues, using in situ proximity-ligation assay (PLA)-based detection with a PSA-specific antibody and 25 different glycan-binding lectins.

Results

Using 25 different lectins and a small tissue microarray (TMA), we showed that glycosylation of PSA in cancerous tissues is different from that in benign prostate. In a larger TMA with samples from 162 patients, PSA-glycoforms detected by succinylated wheat

SUBMITTER: Koistinen H 

PROVIDER: S-EPMC12379856 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature