Dataset Information

Patterns of Teprotumumab-Induced Hearing Dysfunction: A Systematic Review.

ABSTRACT:

Objective

Hearing loss has been reported after administration of the monoclonal antibody teprotumumab. The purpose of this study was to review available evidence regarding the patterns of teprotumumab-related ototoxicity.

Data sources

PubMed, EMBASE, and Cochrane Library.

Review methods

A systematic review was performed using standardized methodology. Studies were included if they included subjects who were prescribed teprotumumab. Exclusion criteria included non-English articles, abstracts, letters/commentaries, case reports, and reviews. Subjects without both pre- and posttreatment audiometric data were also excluded. Bias was assessed using the Mixed Methods Appraisal Tool.