Phosphate Improves Mitochondrial Function and Reduces Pancreatitis in Hypertriglyceridemia.

ABSTRACT: Hypertriglyceridemia-associated pancreatitis (HTGP) accounts for 9% to 10% of acute pancreatitis; however, the exact cause and associated factors advancing HTGP are unclear. Clinical studies have revealed that hypophosphatemia is a common factor in many patients with pancreatitis. Phosphate depletion occurs in metabolic disorders and can lead to dyslipidemia. To determine if phosphate status is critical in HTGP, we used an APOC3 transgenic mouse model of hypertriglyceridemia. We found that hypertriglyceridemic mice exhibit mild pancreatic injury with elevated intra-acinar nonendoplasmic reticulum (non-ER) organelle calcium levels, decreased mitochondrial function, and increased levels of pancreatic tissue myeloperoxidase and proinflammatory cytokines (TNF-α, IL-6, and IL-1β) compared to mi

SUBMITTER: Mullappilly N 

PROVIDER: S-EPMC12380037 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature