Plasma Metabolomics Profiles in Prodromal and Clinical Parkinson's Disease.

ABSTRACT:

Background

The long prodromal phase of Parkinson's disease (PD) and the link the disease has with metabolic factors suggest that metabolomics could help identify affected individuals at early stages.

Objective

The goal was to examine whether plasma metabolomic profiles could identify individuals in the prodromal and clinical phase of PD.

Methods

We quantified and compared the plasma metabolomic profiles of 922 individuals with PD who provided blood samples at a median of 11 years before (n = 809) or 2 years after (n = 113) disease diagnosis to that of matched controls, all selected from three established cohort studies (Nurses' Health Study, Health Professionals Follow-up Study, and Cancer Prevention Study II). We used conditional logistic regression models and machin

SUBMITTER: Flores-Torres MH 

PROVIDER: S-EPMC12380052 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature