Association of Early-life Trauma With Gestational Diabetes and Hypertensive Disorders of Pregnancy.

ABSTRACT:

Background

Early-life trauma (before age of 18 years) is hypothesized to increase the risk for adverse pregnancy outcomes through stress pathways, yet epidemiologic findings are mixed.

Methods

Sister Study participants (US women aged 35-74 years enrolled 2003-2009) completed an adapted Brief Betrayal Trauma Survey at the first follow-up visit. Lifetime history of gestational diabetes mellitus (GDM) or hypertensive disorders of pregnancy (HDP: pregnancy-related high blood pressure, pre-eclampsia/toxemia, or eclampsia) in pregnancies lasting ≥20 weeks was self-reported. We used log-binomial regression to estimate relative risks (RR) and 95% confidence intervals (CIs) for the association between early-life trauma (modeled using conventional measures [e.g., any experience, subst

SUBMITTER: Lovett SM 

PROVIDER: S-EPMC12380080 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature