Reward-driven cerebellar climbing fiber activity influences both neural and behavioral learning.

ABSTRACT: The cerebellum plays a key role in motor coordination and learning. In contrast to classical supervised learning models, recent work has revealed that climbing fibers (CFs) can signal reward-predictive information in some behaviors. This raises the question of whether CFs may also operate according to the principles of reinforcement learning. To test how CFs operate during reward-guided behavior and evaluate the role of reward-related CF activity in learning, we measured CF responses in Purkinje cells of the lateral cerebellum during a Pavlovian task using two-photon calcium imaging. Specifically, we have performed multi-stimulus experiments to determine whether CF activity meets the requirements of a reward prediction error (rPE) signal for transfer from an unexpected reward to a reward-p

SUBMITTER: Jin S 

PROVIDER: S-EPMC12380153 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature