Low prevalence of glomerulonephritis in transplanted kidneys from deceased donors with active hepatitis C virus infection.

ABSTRACT: Hepatitis C virus (HCV) infection is a leading cause of immune-complex mediated glomerulonephritis, specifically cryoglobulinemic and membranoproliferative glomerulonephritis, and has also been associated with non-glomerular kidney diseases. However, the prevalence of kidney disease among individuals with chronic HCV infection is unknown. Concerns about the quality of kidneys from deceased donors with HCV infection may lead centers to avoid transplanting these organs. We assembled a multicenter histological database of deceased donor biopsies to compare the prevalence of glomerulonephritis and chronic disease pathology among 147 transplanted kidneys from HCV-RNA+ donors matched to 431 HCV-negative donors. The mean age was 40.3 versus 40.7 years for HCV-RNA+ versus HCV-negative donors, resp

SUBMITTER: Reese PP 

PROVIDER: S-EPMC12380177 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature