Neural correlates of concern about falling in multiple sclerosis: resting-state functional connectivity in amygdala-hippocampal and amygdala-cerebellar circuits.

ABSTRACT:

Background

Concern about falling (CAF) is common in multiple sclerosis (MS), impacting motor function, cognition, and emotional well-being. However, the underlying neural correlates remain understudied. Given the multifactorial nature of CAF, we hypothesized that neural correlates may involve interactions between brain regions involved in emotional (e.g., amygdala), motor (e.g., cerebellum), and cognitive functions (e.g., hippocampus). This study explored associations between CAF and resting-state functional connectivity (FC) in amygdala-hippocampal and amygdala-cerebellar circuits in MS.

Methods

Participants with relapsing-remitting MS completed the Falls Efficacy Scale-International to assess CAF, followed by a functional MRI scan. Region of interest (ROI)-to-ROI analyses

SUBMITTER: Takla TN 

PROVIDER: S-EPMC12380195 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature