Hemocyanin controls Vibrio levels in hemolymph by modulating intracellular ROS via p38 MAPK.

ABSTRACT: Redox reactions are essential for various biological processes, hence, maintaining redox homeostasis is critical for cellular health and host-microbe interactions, particularly in marine invertebrates, where these processes remain poorly understood. This study investigates the role of the respiratory protein hemocyanin in regulating redox-related genes, reactive oxygen species (ROS) levels in shrimp hemocytes, and its influence on immune function and hemolymph Vibrio abundance. Our results show that hemocyanin is crucial in the regulation of the redox system, as hemocyanin knockdown disrupts the expression of antioxidant (PvPOD and PvGPX) and pro-oxidant (PvXOX) genes and redox enzyme activities, leading to elevated ROS levels in hemocytes. Additionally, we found that hemocyanin controls r

SUBMITTER: Cheng J 

PROVIDER: S-EPMC12380221 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature