Chondrocalcinosis and incident knee osteoarthritis: findings from 2 large prospective cohorts with 20 years of follow-up.

ABSTRACT:

Objectives

Chondrocalcinosis, a radiographic feature of calcium crystal deposition, is frequently observed alongside osteoarthritis. Although cross-sectional studies suggest an association, it remains unclear whether chondrocalcinosis is a consequence or a contributing factor in osteoarthritis development. This study investigates its role as a potential risk factor for incident knee osteoarthritis and knee pain in 2 large longitudinal cohorts: the Rotterdam Study (RS) and the Multicenter Osteoarthritis Study (MOST).

Methods

This prospective cohort study analysed 20-year follow-up data from 3737 participants in RS and 7-year follow-up data from 2750 in MOST. We examined the association of baseline knee chondrocalcinosis with (1) incident radiographic knee osteoarthritis and (

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12380518 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature