HLA loci heterozygosity modulates genetic risk in idiopathic inflammatory myopathies.

ABSTRACT:

Objectives

Idiopathic inflammatory myopathies (IIMs) are rare autoimmune disorders. Genetic association studies have highlighted the role of human leukocyte antigen (HLA) polymorphisms in IIM. We aimed to characterise the nonadditive effects (dominance and interaction) of HLA alleles on IIM risk.

Methods

This study included a total of 3206 IIM cases and 11,697 controls of European ancestry. HLA alleles were imputed using a multiancestry HLA reference panel. Logistic regressions were conducted to estimate the nonadditive effects of HLA alleles. Clinical subgroup analysis, calculation of phenotypic variance explained, and stepwise conditional analyses were conducted to further characterise these effects.

Results

We identified significant nonadditive effects in 5 HLA gen

SUBMITTER: Chen G 

PROVIDER: S-EPMC12380519 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature