A Decoy Oligodeoxynucleotides Disturbing Forkhead Box O3 Mediated ctnna2 Transcriptional Repression Prevents Postoperative Neurocognitive Disorder in Mice.

ABSTRACT: Perioperative cognitive disorder (PND) affects up to 31% of surgical patients. Although clinical studies have identified a variety of risk factors, no effective prevention has been developed. From our previous cohort of PND patients, several single-nucleotide polymorphism (SNP) sites on ctnna2 were identified. The current study aims to decipher the role and regulatory mechanism of ctnna2 in the PND model and to develop decoy oligodeoxynucleotides (decoy) for the possible prevention of PND. Both mice model (exploratory laparotomy+isoflurane) and the neuronal model (TNFα+isoflurane, T + I) for PND were used. Bioinformatic research was utilized to identify transcriptive active areas on ctnna2, foxo3 sequence, and to predict possible transcriptional factors for regulation. Molecular biological

SUBMITTER: Wu Z 

PROVIDER: S-EPMC12380581 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature