A comprehensive analysis identifies and validates NPC1 as a potential biomarker for prognosis in HCC.

ABSTRACT: Niemann-Pick type C1 protein (NPC1), a key regulator of intracellular cholesterol transport and a transmembrane protein, has been implicated in carcinogenesis, particularly in hepatocellular carcinoma (HCC). Despite the noted association, the specific role of NPC1 in HCC remains underexplored. In this study, we conducted a comprehensive analysis of NPC1 expression across diverse gene expression databases to elucidate its prognostic significance and functional interactions. Utilizing LinkedOmics for co-expression network analysis and KEGG for functional enrichment, we identified a set of genes co-expressed with NPC1 and its associated biological pathways. Our findings demonstrate that NPC1 is frequently upregulated and amplified in HCC tumor tissues, with higher expression levels significan

SUBMITTER: Lu X 

PROVIDER: S-EPMC12380838 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature