Targeted and safe delivery of colchicine via polymeric nanocarriers for potential atherosclerosis therapy with in vitro and in vivo evaluation.

ABSTRACT: This study highlights the potential of nanoparticle-encapsulated colchicine as a safer and more effective alternative to free colchicine for treating atherosclerotic vascular disease (ASCVD). While colchicine is known for its anti-inflammatory properties, its dose-dependent toxicity limits long-term clinical use. To address this issue, colchicine was encapsulated in polymeric nanoparticles synthesized through a microfluidic method using methylated β-cyclodextrin as the initiator. The resulting formulation achieved an encapsulation efficiency of 30% and a drug loading capacity of 75%, indicating a high payload capability. This approach not only demonstrated high drug-loading efficiency but also enabled controlled release, with approximately 60% of the drug being released over 96 h. The nano

SUBMITTER: Tomaszewska A 

PROVIDER: S-EPMC12380999 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature