Causal relationship between Alzheimer's disease and cerebral small vessel disease: a Mendelian randomization study.

ABSTRACT: Observational studies have produced inconsistent findings regarding the relationship between Alzheimer's disease (AD) and cerebral small vessel disease (CSVD) risk. Residual confounding and potential reverse causality are inevitable in such conventional observational studies. We tried to examine the causal relationship between AD and CSVD-related phenotypes using genetic methods. Genetic instruments for each AD and CSVD-related phenotypes (cerebral microbleeds, white matter hyperintensity, and lacunar stroke) were derived from large-scale genome-wide association studies. In this study, two-sample Mendelian randomization (MR) tested potential causal associations between AD and CSVD-related phenotypes, followed by a colocalization analysis to corroborate MR findings and explain possible mech

SUBMITTER: Liu R 

PROVIDER: S-EPMC12381051 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature