Characterization of rhesus macaque model for cobalt-60 gamma-radiation source without use of blood product.

ABSTRACT: Despite significant radiobiological advancements following World War II, only a limited number of medical countermeasures (MCMs) have been approved by the United States Food and Drug Administration (US FDA) for acute radiation exposure related illnesses. Accordingly, well-characterized and validated animal models, both large and small, are still very much needed to develop safe and effective countermeasures. Animal models that are used for such purposes need to reflect not only the clinical and pathogenic features of those seen in radiation exposed humans, but also comparable radiation dose- and time-dependent relationships. The objective of the present study therefore was to further characterize the response patterns of rhesus nonhuman primates exposed to total-body, potentially lethal, r

SUBMITTER: Wise SY 

PROVIDER: S-EPMC12381090 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature