Serum metabolic profiling in rheumatic heart disease and degenerative aortic stenosis.

ABSTRACT: Metabolomics enables the characterisation of pathogenic and diagnostic biomarkers in cardiovascular disease (CVD). Given the high prevalence of rheumatic heart disease (RHD) and degenerative aortic stenosis (AS) in Africa, we investigated potential discriminant metabolic biomarkers in individuals with severe RHD and AS undergoing valve replacement and compared them to those in matched controls. Untargeted metabolomics of serum samples showed that seven metabolites that were differentially expressed in RHD patients were independent of the patients' baseline characteristics (covariates) and could differentiate RHD patients from healthy controls (AUC > 0.7). Four metabolites could differentiate AS patients from controls (AUC ≥ 0.7). Of the perturbed metabolites in RHD and AS, 7-HOCA and deoxy

SUBMITTER: Mutithu DW 

PROVIDER: S-EPMC12381107 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature