Integrated computational and preclinical evaluation of novel synthetic pyrazole pyrazoline thiazole derivative for breast cancer therapeutics.

ABSTRACT: Breast cancer is the uncontrolled growth of breast cells in the lobules or the inner lining of milk ducts due to dysfunction of regulatory genes. The drugs currently used in breast cancer treatment have severe limitations. The study aimed to test 10 new synthetic forms of pyrazole clubbed pyrazoline thiazole derivatives for their ability to kill tumor cells, reduce inflammation, fight free radicals, and other important factors linked to breast cancer. The study involved computational models to assess ligand-binding affinities and pharmacokinetic properties. Later, we evaluated cytotoxicity using a human breast cancer cell line, MCF-7. In a preclinical model, the levels of vital cytokines like Transforming Growth Factor-β (TGF-β), Tumor Necrosis Factor alpha (TNF-α), and Interleukin- 6 were

SUBMITTER: Shah R 

PROVIDER: S-EPMC12381117 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature