Environmental exposure to perfluorooctane sulfonate and its role in esophageal cancer progression: a comprehensive bioinformatics and experimental study.

ABSTRACT: Esophageal cancer (ESCA) is a significant malignancy with rising global incidence rates and considerable impacts on patient survival and quality of life. Current diagnostic and therapeutic strategies face limitations, necessitating research into its underlying mechanisms and potential biomarkers for early diagnosis. This study aims to investigate the role of perfluorooctane sulfonate (PFOS), an environmental toxicant, in the development of ESCA through a comprehensive bioinformatics approach. Using the TCGA-ESCA dataset, we identified differentially expressed genes (DEGs) and intersected them with PFOS-related toxicity targets predicted via Comparative Toxicogenomics Database (CTD) and SuperPred. Machine learning (Random Forest, XGBoost, LASSO, SVM) were applied to prioritize core targets.

SUBMITTER: Liu F 

PROVIDER: S-EPMC12381176 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature