Differential trajectories of corticostriatal structural connectivity in individuals at clinical high risk for psychosis according to functional outcome.

ABSTRACT: Dysconnectivity in the corticostriatal pathway, which is central to psychosis pathophysiology, is also known to be present in individuals at clinical high risk for psychosis (CHR-P). Considering that the corticostriatal pathway actively matures until adulthood and that neuroanatomical maturation is suggested to be related to functional outcomes in individuals at CHR-P, longitudinal studies on the corticostriatal structural pathway in individuals at CHR-P are warranted. To characterize the longitudinal trajectory of corticostriatal structural connectivity, diffusion-weighted images were collected from 23 individuals at CHR-P and 20 healthy controls (HCs) at baseline and at a 2-year follow-up visit. Probabilistic tractography was performed to segment the pathways between seven cortical regio

SUBMITTER: Choe E 

PROVIDER: S-EPMC12381177 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature