Evaluating in-vivo spontaneous firing rate in the brain based on neuronal noise modeling.

ABSTRACT: Even without external stimuli, neurons produce spontaneous bursts of activities. Theoretical and practical clinical considerations, suggest the importance of determining the in-vivo statistical profile of those spontaneous spikes bursts, however this task has not been accomplished yet. Currently, it is only accepted that the in-vivo value of the mean firing rate (λ) of those spontaneous bursts is below 0.1Hz, without knowing its specific value and its population distribution. Here we propose a framework to evaluate the neurons' λ during rest of a given subject, using stochastic signal processing analysis of in-vivo brain fMRI and EEG. Our main hypothesis is that during rest the input to the neurons is mostly formed by a random neuronal noise, and although it fluctuates with zero mean, it a

SUBMITTER: Dvir H 

PROVIDER: S-EPMC12381194 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature