Profile and evolution of antimicrobial resistance genes in Staphylococcus aureus whole genomes in Africa revealed by phylogeography and bioinformatics.

ABSTRACT: The elaboration of antimicrobial resistance genes (ARGs) in Staphylococcus aureus is a significant public health concern. Despite this concern, the spread and diversity of the ARGs in S. aureus are not fully understood. This study is the first report of the diversity and evolution of ARGs in whole genomes of S. aureus in Africa using a combination of phylogeography and bioinformatics. Whole genomes of S. aureus isolates from Africa were retrieved from the National Centre for Biotechnology Information (NCBI) and were used to infer ARGs diversity and evolution across Africa using the CARD (Comprehensive Antibiotic Resistance Database) and BEAST (Bayesian Evolutionary Analysis Sampling Trees) tools, respectively. The metadata revealed diverse sources from which S. aureus was isolated. Out of

SUBMITTER: Edet UO 

PROVIDER: S-EPMC12381200 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature