A real-world safety signal detection study of ondansetron based on FAERS reports from 2014 to 2024.

ABSTRACT: Ondansetron is widely acknowledged for its effectiveness in preventing and treating postoperative nausea and vomiting. Nevertheless, comprehensive research on its adverse effects is still limited. This study intends to explore the adverse events (AEs) related to Ondansetron, making use of data from the FDA Adverse Event Reporting System (FAERS) in the past decade. A pharmacovigilance analysis was carried out using FAERS data from January 2014 to March 2024. Disproportionality analysis was utilized with four algorithms-proportional reporting ratio (PRR), reporting odds ratio (ROR), information component (IC), and empirical Bayesian geometric mean (EBGM)-to detect signals related to Ondansetron-related AEs. From Q1 2014 to Q1 2024, 9,413 adverse event (AE) reports were linked to Ondansetron

SUBMITTER: Yang F 

PROVIDER: S-EPMC12381205 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature