Deep adversarial learning identifies ADHD-specific associations between apoptotic genes and white matter microstructure in frontal-striatum-cerebellum circuit.

ABSTRACT: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by genetic predisposition and alterations in brain structural connectivity. While existing studies have established associations between genetic variants and neuroanatomical features, the specific relationships in ADHD remained poorly understood. To address this gap, we developed adversarial deep canonical correlation analysis models (A-DCCA) to disentangle ADHD-specific and non-specific "gene-white matter" association patterns. Utilizing diffusion tensor imaging and genotype data from six-hundred ADHD and typically developed children in a Chiese cohort, the current study revealed ADHD-specific correlations between the right cerebral peduncle, right posterior limb of the internal capsule, and gen

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12381256 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature