Combining serologic biomarkers with the PAGE B score improves risk stratification for hepatocellular carcinoma development among chronic hepatitis B patients.

ABSTRACT: Early-stage diagnosis of Hepatocellular Carcinoma (HCC) vastly improves outcomes for patients. However, most patients are diagnosed late-stage when their only option is palliative treatment. In this study we propose a risk stratification method that combines cutoffs for PAGE-B with cutoffs for a prototype serological immunoassay, LG2m, as well as 2 conformité européenne (CE)-certified serological immunoassays in AFP and PIVKA-II run on the high-throughput ARCHITECT (Abbott Laboratories, North Chicago, IL) instrument. In this study, immunoassays for LG2m, PIVKA-II, and AFP were used to test serial plasma from 1329 Asian chronic hepatitis B (CHB) patients at baseline, year 1, year 3, and year 5. These CHB patients were put on first-line nucleos(t)ide analogue (NA) therapy and monitored for h

SUBMITTER: Stec M 

PROVIDER: S-EPMC12381259 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature