Enrichment of Streptococcus oralis in respiratory microbiome enhance innate immunity and protects against influenza infection.

ABSTRACT: Respiratory microbial dysbiosis has been implicated in the occurrence and progression of community-acquired pneumonia (CAP). However, the dynamic variation in the respiratory microbiota and its interaction with the host response remain poorly understood. Here, we performed metagenomic analysis of respiratory and gut microbiota, along with blood transcriptomics, using longitudinally collected samples from 38 CAP patients. CAP patients presented disrupted sputum microbiota at the early, middle, and late stages of hospitalization. Microbial pathways involved in peptidoglycan biosynthesis and immune evasion, particularly contributed by the Streptococcus genus, were enriched in CAP patients. Additionally, several Streptococcus strains demonstrated correlation between respiratory and gut microbi

SUBMITTER: Zou X 

PROVIDER: S-EPMC12381301 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature