Association Between Vaccination for Human Papillomavirus (HPV) and Autonomic Dysfunction and Menstrual Irregularities: A Self-Controlled Case Series Analysis.

ABSTRACT:

Background

Limited research has addressed safety concerns related to vaccination against the human papillomavirus (HPV).

Objective

To investigate the association between receipt of HPV vaccination and autonomic dysfunction and menstrual irregularities in girls and young women.

Methods

Using a 25% random sample of IQVIA PharMetrics^® Plus for Academics claims database from 2016 to 2020, we conducted a self-controlled case series study in commercially insured girls and young women receiving their first HPV vaccine dose (analyses conducted between March 2024 and April 2025). Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were estimated for two outcomes-autonomic dysfunction and menstrual irregularities. We conducted further analyses stratified

SUBMITTER: Wastila L 

PROVIDER: S-EPMC12381344 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature