Cerebrospinal Fluid Cytokine and Chemokine Analysis in Dogs With Meningoencephalitis of Unknown Origin or Idiopathic Epilepsy.

ABSTRACT: Current diagnosis of brain disease in dogs is dependent on imaging and cerebrospinal fluid (CSF) analysis, including total nucleated cell counts and albumin concentrations. To determine whether multiplex cytokine/chemokine (Ct/Cm) analysis can differentiate among dogs with meningoencephalitis of unknown origin (MUE), idiopathic epilepsy (IE), and brain neoplasia. Client owned dogs diagnosed with brain disease with MRI and CSF diagnostics. Groups included 18 dogs with a diagnosis of MUE, 21 dogs with IE, and 7 dogs with brain tumors. A retrospective observational study; a multiplex immunoassay was utilized to measure CSF concentrations for the following: Interleukin (IL)-2, IL-6, IL-7, IL-8, IL-10, IL-15, and IL-18, granulocyte macrophage colony-stimulating factor (GM-CSF), interferon gamma

SUBMITTER: Byron MJ 

PROVIDER: S-EPMC12381357 | biostudies-literature | 2025 Sep-Oct

REPOSITORIES: biostudies-literature