Factors associated with age at tau pathology onset and time from tau onset to dementia in Alzheimer's disease.

ABSTRACT:

Introduction

Elevated tau (T+) is temporally proximal to dementia onset but less is known about factors influencing T+ onset age and time to dementia after T+ in Alzheimer's disease (AD). We used sampled iterative local approximation (SILA) estimated T+ onset age (ETOA) to investigate factors associated with T+ age and time from T+ to dementia onset in the Alzheimer's Disease Neuroimaging Initiative.

Methods

Using SILA-estimated amyloid positivity and T+ onset ages derived from ¹⁸F-Flortaucipir, ¹⁸F-Florbetapir, and ¹⁸F-Florbetaben positron emission tomography and Cox proportional hazards and accelerated failure time models, we analyzed apolipoprotein E (APOE), sex, amyloid burden, age, educational attainment, and literacy associations with E

SUBMITTER: Heston MB 

PROVIDER: S-EPMC12381359 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature