Prescription Drugs in Pregnancy and Congenital Malformations: A Population-Based Safety Screening Study.

ABSTRACT: Counseling women who are either pregnant or contemplating pregnancy on their use of prescribed drugs remains a major clinical challenge. Since the thalidomide tragedy in the 1960s, the use of drugs during pregnancy has been subject to widespread concern due to the potential for unwanted effects on the unborn child, notably major congenital malformations. To examine the risk of major congenital malformations following first trimester exposure to all marketed prescription drugs in Denmark. This was a population-based cohort study utilizing national health registries in Denmark. We studied all singleton livebirths in Denmark between January 1, 2004, and December 31, 2017, and we linked data from the National Danish Prescription Register, Birth Register, Patient Register, and Cause of Death Re

SUBMITTER: Broe A 

PROVIDER: S-EPMC12381547 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature