Metamizole induces voriconazole metabolism and results in subtherapeutic voriconazole concentrations.

ABSTRACT:

Aims

Voriconazole is extensively metabolized via cytochrome P450 (CYP) enzymes, predominantly CYP2C19 and CYP3A4. Drugs influencing the activity or expression of CYP enzymes can cause clinically relevant changes in the metabolism and voriconazole exposure. Metamizole is known to induce CYP3A4 and CYP2C19. This study aimed to investigate the pharmacokinetic drug-drug interaction between metamizole and voriconazole.

Methods

In this single-centre retrospective observational cohort study, we compared voriconazole serum trough concentrations before, during and after metamizole treatment.

Results

In the 9 included patients, the median voriconazole trough concentration decreased by 71% during metamizole treatment (P = .028) compared to before start of metamizole. The concent

SUBMITTER: Baan SD 

PROVIDER: S-EPMC12381621 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature