Poststroke Cardiorespiratory Exercise for Brain Volume and Cognition: A Randomized Clinical Trial.

ABSTRACT: Stroke increases the risk of cognitive impairment and dementia without proven prevention therapies. Cardiorespiratory exercise (CRX) preserves brain health. To determine whether a CRX intervention preserves hippocampal volume (HV) and cognition in patients after ischemic stroke. The Post-Ischemic Stroke Cardiovascular Exercise Study (PISCES)-Zoom Delivered Intervention Against Cognitive Decline (ZODIAC) is a phase 2b assessor-blinded randomized clinical trial performed at 4 metropolitan health care services in Melbourne, Australia. Eligible participants included adult patients who survived ischemic stroke without comorbidities prohibiting exercise or diagnosed cognitive disorder. Participants were recruited from May 26, 2016, to March 20, 2020, for PISCES in-person training and from Novemb

SUBMITTER: Brodtmann A 

PROVIDER: S-EPMC12381666 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature