Clickable Pyclen-Based Luminescent Lanthanide Complexes: Application to Two-Photon Microscopy.

ABSTRACT: Lanthanide luminescent bioprobes incorporating a reactive group for the functionalization of biomolecules via click chemistry are of high interest for the straightforward preparation of smart luminescent tools for biological imaging and sensing applications. This article describes the synthesis and the photophysical properties of two lanthanide complexes based on the pyclen macrocycle bearing a terminal alkyne group on its pyridine moiety and a 4-(4-alkylthiophenyl)picolinate charge transfer chromophore to sensitize the lanthanide luminescence. The Eu³⁺ and Sm³⁺ complexes show excellent two-photon absorption and emission properties. These complexes were conjugated to a cell penetrating peptide bearing an azide via copper-catalyzed azide-alkyne cycloaddition. The resul

SUBMITTER: Chartier B 

PROVIDER: S-EPMC12381691 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature