Engineering plant holobionts for climate-resilient agriculture.

ABSTRACT: The plant holobiont-an integrated unit of the host and its microbiome-has co-evolved through ecological and genetic interactions. Microbiome engineering offers a promising route to enhance resilience in response to climate stress, soil degradation, and yield stagnation. This review presents an integrated framework combining microbial ecology, synthetic biology, and computational modeling to rationally design synthetic microbial communities (SynComs) for agriculture. We outline ecological principles-priority effects, keystone taxa, and functional redundancy-that shape microbiome assembly and guide SynCom design. Strategies like CRISPR interference, biosensor circuits, and quorum-sensing modules enable programmable microbial functions. We also highlight the predictive potential of in silico

SUBMITTER: Portal-Gonzalez N 

PROVIDER: S-EPMC12381762 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature