Sleep Disturbances Associated With Hidden Hearing Loss: Insights From Human Data and a Mouse Model of Sleep Fragmentation.

ABSTRACT: Sleep disorders have been associated with auditory dysfunction. However, the specific effects of sleep fragmentation (SF) on the peripheral auditory system and the underlying mechanisms remain unclear. Data from the National Health and Nutrition Examination Survey (NHANES) were analyzed to examine the association between sleep disturbances and difficulties in speech perception in noisy environments among participants with normal audiograms. Additionally, an SF mouse model was used to assess the impact of sleep disruption on auditory function and cochlear pathology. Auditory brainstem response (ABR) testing, immunofluorescence staining, and transmission electron microscopy were performed to evaluate the auditory system. NHANES data revealed that individuals with sleep disorders, even with n

SUBMITTER: Wang X 

PROVIDER: S-EPMC12381955 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature