Altered Basal Ganglia Network Topology Associated With Auditory-Motor Synchronization.

ABSTRACT: Auditory-motor synchronization (AMS) embedded in Rhythmic Auditory Stimulation (RAS) is a validated method to improve gait, upper limb function, and motor speech in people with neurologic disorders like Parkinson's disease (PD). Predictable auditory cues optimize spatial movement patterns, and research has suggested that AMS reduces the brain's reliance on dopaminergic (DA) response in the ventral striatum. To gain a mechanistic understanding of the positive clinical outcomes related to AMS, this pilot study investigates the effects of AMS on the basal ganglia network (BGN) using brain network science methods. Fourteen healthy adults (aged 22-37, seven females) completed two fMRI finger tapping tasks, a self-paced continuation (self) task and an auditory-motor synchronized (sync) task, bot

SUBMITTER: Lavigne SK 

PROVIDER: S-EPMC12381958 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature