Structural brain differences in school-aged children who are HIV-exposed uninfected.

ABSTRACT: Antiretroviral therapy (ART) has dramatically reduced perinatal HIV transmission, leading to a growing population of children who are HIV-exposed but uninfected (CHEU). While the neuroanatomic developmental impacts of in utero HIV and ART exposure have been studied in young children, long-term effects on school-aged children are poorly understood, prompting this investigation. Fifty-eight CHEU and 38 children who are HIV-unexposed, uninfected (CHUU), 6-12 years old, were recruited through hospitals and community groups in Ontario, Canada. From T1-weighted magnetic resonance images, volume, cortical thickness, and gray-/white-matter tissue volume were extracted. Multiple linear regression models controlling for sex, age, household income, and total brain volume were fit to assess difference

SUBMITTER: Forster EA 

PROVIDER: S-EPMC12382074 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature