Chromatin remodeling and H3K4me3 depletion regulate germline specification from pluripotency.

ABSTRACT:

Background

Germ cells are the only cells capable of transmitting heritable genetic material to future generations. Epigenetic mechanisms that regulate germ cell formation are essential for optimizing offspring production, which is particularly important in farm animals like chicken. Primordial germ cells (PGCs), the precursors of gametes, could be derived from the pluripotent blastoderm cells (BC) or embryonic stem cell (ESCs) in chicken but the germline induction efficiency remain low and require further improvements.

Methods

We systematically profiled key histone modifications and chromatin states during the germ/soma specification from chicken pluripotent blastoderm cells to either PGCs or fibroblasts to uncover the chromatin regulators that direct the germline specificat

SUBMITTER: Wang S 

PROVIDER: S-EPMC12382137 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature