Atypical mesenchyme in congenital pulmonary airways malformation: a promising new focus.

ABSTRACT: Congenital pulmonary airways malformations (CPAM) belong to a group of rare congenital lung anomalies whose pathological origin is still mostly unknown. The current research project aims to study the possible role of the underlying mesenchyme in CPAM pathophysiology by comparing data from fetal tissue and healthy lung with CPAM. Tissue samples from CPAM patients and healthy adjacent parts were collected during planned surgical resections. Fetal lung tissue obtained from abortions was also used. The mesenchymal parts of pathological, healthy and fetal lung tissues were analyzed using quantitative proteomic, bulk RNA sequencing and multiplex immunohistochemistry to identify the difference in genes and proteins expressed in CPAM. When compared to healthy adjacent lung tissue, transcriptomic d

SUBMITTER: Azar P 

PROVIDER: S-EPMC12382140 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature