The causal effects of remnant cholesterol on increased risk of cardiovascular diseases in East Asians.

ABSTRACT:

Background

Remnant cholesterol (RC) has been implicated in cardiovascular diseases (CVDs) in populations of European ancestry, yet its causal role remains underexplored in populations of East Asian ancestry, which are underrepresented in genetic studies. We sought to investigate the causal association between circulating RC levels and CVD risk in East Asian populations.

Methods

We first conducted observational analyses of RC and multiple CVD outcomes in Chinese populations. We then conducted genome-wide association studies (GWAS) of RC in 14,939 Chinese individuals and assessed its causal associations with CVD risk using two-sample Mendelian randomization (MR) with Biobank Japan data. Replication analyses in European ancestry populations utilized summary statistics from the

SUBMITTER: Lin C 

PROVIDER: S-EPMC12382207 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature