Evaluation of different lymph node classification systems as independent prognosticators in gastric signet ring cell carcinoma.

ABSTRACT:

Background

Accurate staging is essential in cancer care. The American Joint Committee on Cancer (AJCC) TNM staging system is commonly used but is subject to the risk of stage migration. Recent literature suggests that the log odds of positive lymph nodes (LODDS) and positive lymph node ratio (LNR) may have superior predictive values and are considered alternatives to the N-category. However, their predictive performance in gastric signet ring cell carcinoma (GSRC) remains vague. This study aims to explore the association between three lymph node (LN) staging systems (AJCC N-category, LODDS, and LNR) and outcomes in GSRC, and assess the predictive power.

Methods

Eligible patients with GSRC from 2004 to 2015 were collected from the Surveillance, Epidemiology, and End Results d

SUBMITTER: Wang LF 

PROVIDER: S-EPMC12382296 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature