Revisiting guidance on population sampling for highly polymorphic STR loci.

ABSTRACT: Population databases allow us to attach probabilities to DNA evidence by the estimation of genotype frequencies, which rely on accurate allele frequency estimates. As short tandem repeat (STR) marker sets for human identification have expanded to include more discriminating markers, and especially now that sequencing techniques allow us to distinguish between alleles based on variation in underlying base-pair structure, it is important to reevaluate existing guidance on population database sizes for the estimation of allele frequencies. In this paper, we revisit the topic of population sampling by focusing on the representation of alleles, i.e. whether alleles are observed or not, in a sample of individuals containing data for highly polymorphic autosomal STR loci. The effect of both lengt

SUBMITTER: Aalbers SE 

PROVIDER: S-EPMC12382342 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature