CD24 recruits tumor-associated neutrophils to promote the progression of hepatocellular carcinoma.

ABSTRACT:

Background

The immunosuppressive tumor microenvironment is a significant challenge in the treatment of hepatocellular carcinoma (HCC), necessitating the urgent development of strategies to mitigate its effects.

Methods

The application of bioinformatics methods to predict the expression level of CD24 in HCC and its relationship with the occurrence and development of HCC. Gene-engineered mice and flow cytometry were used to study the immune cell populations regulated by CD24. Cell metabolism analysis, western blotting, and lactate content measurement were employed to assess the impact of CD24 on lactate secretion by HCC cells. Additionally, cell counting kit 8 and colony formation assays were conducted to evaluate the effect of CD24 on the sensitivity of HCC cells to sorafenib

SUBMITTER: Wang J 

PROVIDER: S-EPMC12382581 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature