Identification of Druggable Targets for Alzheimer's Disease by Analyzing Circulating Inflammatory Proteins With Mendelian Randomization.

ABSTRACT: To identify potential druggable targets for Alzheimer's disease (AD) by analyzing circulating inflammatory proteins using Mendelian randomization (MR). Two-sample MR analysis was employed to investigate the causal relationships between 91 circulating inflammatory proteins and AD. The primary MR method utilized was the inverse variance weighted (IVW) model, while the weighted median (WM) and MR-Egger models were applied for sensitivity analysis. To assess the heterogeneity of instrumental variables (IVs), Cochran's Q-test and I2 statistics were utilized. Additionally, ChEMBL and DGIdb databases with Bayesian colocalization analysis were consulted to identify potential druggable proteins. MR analysis identified eight inflammatory proteins significantly associated with AD risk. Among these pr

SUBMITTER: An H 

PROVIDER: S-EPMC12382734 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature