Activation of Focal Adhesion Pathway by <i>CIDEA</i> as Key Regulatory Axis in Lipid Deposition in Goat Intramuscular Precursor Adipocytes.

ABSTRACT: Intramuscular fat (IMF) content determines the quality of goat meat and is regulated by the comprehensive effect of the proliferation and adipogenesis of intramuscular preadipocytes. Our previous RNA-seq data revealed that cell death-inducing DNA fragmentation factor alpha (DFFA)-like effector (CIDE) A was upregulated during the development of intramuscular fat in the longissimus dorsi muscle tissue, implying an important role in lipid homeostasis. However, the mechanism by which CIDEA, a member of the CIDE family, regulates intramuscular fat deposition in goat muscle is unknown, so we explored the function and underlying mechanism of CIDEA in goat intramuscular preadipocytes. To address this, we altered CIDEA in intramuscular preadipocytes and resolved the effect and

SUBMITTER: Shao P 

PROVIDER: S-EPMC12383094 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature