Comprehensive Analysis of Liver Transcriptome and Metabolome Response to Oncogenic Marek's Disease Virus Infection in Wenchang Chickens.

ABSTRACT: Marek's disease (MD), induced by the highly contagious Marek's disease virus (MDV), remains a significant challenge to global poultry health despite extensive vaccination efforts. This study employed integrated transcriptomic and metabolomic analyses to investigate liver responses in naturally MDV-infected Wenchang chickens during late infection stages. RNA sequencing identified 959 differentially expressed genes (DEGs) between the infected and uninfected groups. Functional enrichment analysis demonstrated that these DEGs were primarily associated with canonical pathways related to metabolism and cellular processes, including lipid, carbohydrate, and amino acid metabolism, as well as the p53 signaling pathway, cell cycle, and apoptosis. Ultra-high-performance liquid chromatography coupled

SUBMITTER: Zhi L 

PROVIDER: S-EPMC12383417 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature